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Article

Levels of the origin-binding protein Double parked and its inhibitor Geminin increase in response to replication stress.

Journal of cell science - 15 Sept 2005

May Noah R, Thomer Marguerite, Murnen Katherine F, Calvi Brian R

Abstract excerpt

The regulation of a pre-replicative complex (pre-RC) at origins ensures that the genome is replicated only once per cell cycle. Cdt1 is an essential component of the pre-RC that is rapidly degraded at G1-S and also inhibited by Geminin (Gem) protein to prevent re-replication. We have previously shown that destruction of the Drosophila homolog of Cdt1, Double-parked (Dup), at G1-S is dependent upon cyclin-E/CDK2...

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Source

Identifiers

PMID: 16141238
DOI: 10.1242/jcs.02534

Genes

ATM
ATR
CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Levels of the origin-binding protein Double parked and its inhibitor Geminin increase in response to replication stress.PMID 16141238Read ↗

Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2.Semantic proximity Read ↗

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Drosophila double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts.Semantic proximity Read ↗

Distinct and sequential re-replication barriers ensure precise genome duplicationSemantic proximity Read ↗

Mitosis without DNA replication in mammalian somatic cellsSemantic proximity Read ↗

Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects.Semantic proximity Read ↗

Geminin prevents rereplication during xenopus development.Semantic proximity Read ↗

Human Cdt1 lacking the evolutionarily conserved region that interacts with MCM2-7 is capable of inducing re-replication.Semantic proximity Read ↗

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