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Rereplication by Depletion of Geminin Is Seen Regardless of p53 Status and Activates a G<sub>2</sub>/M Checkpoint

28 Jul 2004

Abstract excerpt

Genomic DNA replication is tightly controlled to ensure that DNA replication occurs once per cell cycle; loss of this control leads to genomic instability. Geminin, a DNA replication inhibitor, plays an important role in regulation of DNA replication. To investigate the role of human geminin in the maintenance of genomic stability, we eliminated geminin by RNA interference in human cancer cells. Depletion of...

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Identifiers

PMID: 15282313
DOI: 10.1128/mcb.24.16.7140-7150.2004

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Related research

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Research trail→

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Rereplication by Depletion of Geminin Is Seen Regardless of p53 Status and Activates a G<sub>2</sub>/M CheckpointPMID 15282313Read ↗

Loss of Geminin induces rereplication in the presence of functional p53Semantic proximity Read ↗

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Cell cycle-dependent subcellular translocation of the human DNA licensing inhibitor geminin.Semantic proximity Read ↗

ATR Pathway Is the Primary Pathway for Activating G2/M Checkpoint Induction After Re-replicationSemantic proximity Read ↗

Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.Semantic proximity Read ↗

Geminin is required for zygotic gene expression at the Xenopus mid-blastula transition.Semantic proximity Read ↗

The destruction box of human Geminin is critical for proliferation and tumor growth in human colon cancer cells.Semantic proximity Read ↗

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