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Article

Repression of nascent strand elongation by deregulated Cdt1 during DNA replication in Xenopus egg extracts.

Molecular biology of the cell - 1 Feb 2009

Tsuyama Takashi, Watanabe Saori, Aoki Ayako, Cho Yunje, Seki Masayuki, Enomoto Takemi, Tada Shusuke

Abstract excerpt

Excess Cdt1 reportedly induces rereplication of chromatin in cultured cells and Xenopus egg extracts, suggesting that the regulation of Cdt1 activity by cell cycle-dependent proteolysis and expression of the Cdt1 inhibitor geminin is crucial for the inhibition of chromosomal overreplication between S phase and metaphase. We analyzed the consequences of excess Cdt1 for DNA replication and found that increased Cdt1...

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Identifiers

PMID: 19064889
DOI: 10.1091/mbc.e08-06-0613
PMCID: PMC2633378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Repression of nascent strand elongation by deregulated Cdt1 during DNA replication in Xenopus egg extracts.PMID 19064889Read ↗

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