Article
A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse.
Genetics - 1 Mar 2007
Rubio-Aliaga Isabel, Soewarto Dian, Wagner Sibylle, Klaften Matthias, Fuchs Helmut, Kalaydjiev Svetoslav, Busch Dirk H, Klempt Martina, Rathkolb Birgit, Wolf Eckhard, Abe Koichiro, Zeiser Stefan, Przemeck Gerhard K H, Beckers Johannes, de Angelis Martin Hrabé
Abstract excerpt
The Notch signaling pathway is an evolutionarily conserved transduction pathway involved in embryonic patterning and regulation of cell fates during development. Recent studies have demonstrated that this pathway is integral to a complex system of interactions, which are also involved in distinct human diseases. Delta1 is one of the known ligands of the Notch receptors. Mice homozygous for a loss-of-function...
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