Article
An ENU-mutagenesis screen in the mouse: identification of novel developmental gene functions.
PloS one - 29 Apr 2011
Wansleeben Carolien, van Gurp Léon, Feitsma Harma, Kroon Carla, Rieter Ester, Verberne Marlies, Guryev Victor, Cuppen Edwin, Meijlink Frits
Abstract excerpt
BACKGROUND: Mutagenesis screens in the mouse have been proven useful for the identification of novel gene functions and generation of interesting mutant alleles. Here we describe a phenotype-based screen for recessive mutations affecting embryonic development. METHODOLOGY/PRINCIPAL FINDINGS: Mice were mutagenized with N-ethyl-N-nitrosourea (ENU) and following incrossing the offspring, embryos were analyzed at...
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