Article
Generation of ENU-induced mouse mutants with hypocholesterolemia: novel tools for dissecting plasma lipoprotein homeostasis.
Lipids - 1 Aug 2007
Aigner Bernhard, Rathkolb Birgit, Mohr Manuela, Klempt Martina, Hrabé de Angelis Martin, Wolf Eckhard
Abstract excerpt
Pathologic plasma lipoprotein cholesterol levels play a key role in the development and pathogenesis of human atherosclerotic cardiovascular diseases. Plasma cholesterol homeostasis is regulated by genetic predispositions and environmental factors. Animal models showing aberrant plasma cholesterol levels are used for the identification and analysis of novel causative genes. Here, we searched for inherited...
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