Article
Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in plasma enzyme activities as novel organ-specific disease models.
Experimental physiology - 1 Apr 2009
Aigner Bernhard, Rathkolb Birgit, Klaften Matthias, Sedlmeier Reinhard, Klempt Martina, Wagner Sibylle, Michel Dian, Mayer Ulrike, Klopstock Thomas, de Angelis Martin Hrabé, Wolf Eckhard
Abstract excerpt
Measurement of plasma enzyme activities is part of routine medical examination protocols and provides valuable parameters for the diagnosis of various organ diseases. In the phenotype-driven Munich N-ethyl-N-nitrosourea (ENU) mouse mutagenesis project, clinical chemical blood analysis was carried out on more than 20,000 G1 and G3 offspring of chemically mutagenized inbred C3H mice to detect dominant and recessive...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.