Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models.

American journal of physiology. Renal physiology - 1 May 2007

Aigner Bernhard, Rathkolb Birgit, Herbach Nadja, Kemter Elisabeth, Schessl Christina, Klaften Matthias, Klempt Martina, de Angelis Martin Hrabé, Wanke Rüdiger, Wolf Eckhard

Abstract excerpt

Kidney diseases lead to the failure of urinary excretion of metabolism products. In the Munich ethylnitrosourea (ENU) mouse mutagenesis project, which is done on a C3H inbred genetic background, blood samples of more than 15,000 G1 offspring and 500 G3 pedigrees were screened for alterations in clinical-chemical parameters. We identified 44 animals consistently exhibiting increased plasma urea concentrations....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Creatinine
Share to Ethylnitrosourea

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Diseases

Share to Kidney Glomerulus

Share to Mice, Inbred C3H

Share to Mice, Mutant Strains

Share to Organ Size

Source

Identifiers

PMID: 17264314
DOI: 10.1152/ajprenal.00213.2006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models.PMID 17264314Read ↗

Large-scale albuminuria screen for nephropathy models in chemically induced mouse mutants.Semantic proximity Read ↗

Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in plasma enzyme activities as novel organ-specific disease models.Semantic proximity Read ↗

Mammalian urea transportersSemantic proximity Read ↗

N-ethyl-N-nitrosourea mutagenesis produced a small number of mice with altered plasma electrolyte levels.Semantic proximity Read ↗

Large-scale production of mouse phenotypes: the search for animal models for inherited diseases in humans.Semantic proximity Read ↗

Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice.Semantic proximity Read ↗

Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice.Semantic proximity Read ↗

A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy.Semantic proximity Read ↗

A mouse model for cystinuria type I.Semantic proximity Read ↗

Implications of Genetic Factors Underlying Mouse Hydronephrosis: Cautionary Considerations on Phenotypic Interpretation in Genetically Engineered Mice.Semantic proximity Read ↗

Generation of ENU-induced mouse mutants with hypocholesterolemia: novel tools for dissecting plasma lipoprotein homeostasis.Semantic proximity Read ↗

Urea transporter knockout mice and their renal phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.