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Article

A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the rat.

The Journal of biological chemistry - 29 Jul 2011

Mul Joram D, Nadra Karim, Jagalur Noorjahan B, Nijman Isaac J, Toonen Pim W, Médard Jean-Jacques, Grès Sandra, de Bruin Alain, Han Gil-Soo, Brouwers Jos F, Carman George M, Saulnier-Blache Jean-Sébastien, Meijer Dies, Chrast Roman, Cuppen Edwin

Abstract excerpt

The Lpin1 gene encodes the phosphatidate phosphatase (PAP1) enzyme Lipin 1, which plays a critical role in lipid metabolism. In this study we describe the identification and characterization of a rat model with a mutated Lpin1 gene (Lpin1(1Hubr)), generated by N-ethyl-N-nitrosourea mutagenesis. Lpin1(1Hubr) rats are characterized by hindlimb paralysis and mild lipodystrophy that are detectable from the second...

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Identifiers

PMID: 21715287
DOI: 10.1074/jbc.M110.197947
PMCID: PMC3143639

Genes

LPIN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the rat.PMID 21715287Read ↗

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