Article
Novel phenotypes identified by plasma biochemical screening in the mouse.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 2002
Hough Tertius A, Nolan Patrick M, Tsipouri Vicky, Toye Ayo A, Gray Ian C, Goldsworthy Michelle, Moir Lee, Cox Roger D, Clements Sian, Glenister Peter H, Wood John, Selley Rachael L, Strivens Mark A, Vizor Lucie, McCormack Stefan L, Peters Josephine, Fisher Elizabeth M, Spurr Nigel, Rastan Sohaila, Martin Joanne E, Brown Steve D M, Hunter A Jacqueline
Abstract excerpt
We used ENU mutagenesis in the mouse for the rapid generation of novel mutant phenotypes for both gene function studies and use as new animal models of human disease (Nolan et al. 2000b). One focus of the program was the development of a blood biochemistry screen. At 8-12 weeks of age, approximately 300 ml of blood was collected from F1 offspring of ENU mutagenized male mice. This yielded approximately 125 ml of...
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