Article
The T cell receptor V alpha 11 gene family. Analysis of allelic sequence polymorphism and demonstration of J alpha region-dependent recognition by allele-specific antibodies.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 1991
Jameson S C, Nakajima P B, Brooks J L, Heath W, Kanagawa O, Gascoigne N R
Abstract excerpt
Allelic polymorphism in TCR loci may play an important role in shaping the T cell repertoire and in disease susceptibility. We have used a combination of antibody and sequence analysis to investigate polymorphism in the murine V alpha 11 family. Two different antibodies have been analyzed that re...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Base Sequence
- Cytochrome c Group
- Epitopes
- Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
- Isoantibodies
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Oligonucleotides
- Polymorphism, Genetic