Article
Thymic skewing of the CD4/CD8 ratio maps with the T-cell receptor alpha-chain locus.
Current biology : CB - 4 Jun 1998
Sim B C, Aftahi N, Reilly C, Bogen B, Schwartz R H, Gascoigne N R, Lo D
Abstract excerpt
The thymic preference for CD4+ T cells over CD8+ T cells is often attributed to a default pathway favouring CD4+ T cells or to homeostatic mechanisms. It is also clear, however, that T-cell receptor (TCR) preferences for major histocompatibility complex (MHC) class I versus class II binding will strongly influence an individual clone's skewing to the CD4 or CD8 subset. The variable region of each TCR alpha chain...
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