Thymic skewing of the CD4/CD8 ratio maps with the T-cell receptor alpha-chain locus.

doi:10.1016/s0960-9822(98)70276-3

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Article

Thymic skewing of the CD4/CD8 ratio maps with the T-cell receptor alpha-chain locus.

Current biology : CB - 4 Jun 1998

Sim B C, Aftahi N, Reilly C, Bogen B, Schwartz R H, Gascoigne N R, Lo D

Abstract excerpt

The thymic preference for CD4+ T cells over CD8+ T cells is often attributed to a default pathway favouring CD4+ T cells or to homeostatic mechanisms. It is also clear, however, that T-cell receptor (TCR) preferences for major histocompatibility complex (MHC) class I versus class II binding will...

Topics

Animals
CD4 Antigens
CD4-CD8 Ratio
CD8 Antigens
Chromosome Mapping
Genotype
Hematopoietic Stem Cells
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Polymorphism, Genetic
Receptors, Antigen, T-Cell, alpha-beta
Thymus Gland

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