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Article

Control of TCR V alpha-mediated positive repertoire selection and alloreactivity by differential J alpha usage and CDR3 alpha composition.

International immunology - 1 Oct 1997

Torres-Nagel N, Deutschländer A, Herrmann T, Arden B, Hünig T

Abstract excerpt

In rats expressing the f allele of the rat MHC (RT1f), CD8 T cells utilizing the V alpha 8.2 segment are 10-fold overselected during thymic development, resulting in V alpha 8.2 expression by 14% of mature CD8 T cells as compared to 1-2% in MHC congenic strains. In the alloreactive responses of CD8 T cells from RT1f-negative rats against RT1f, V alpha 8.2+ CD8 T cells are also preferentially expanded. Neither...

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Identifiers

PMID: 9352349
DOI: 10.1093/intimm/9.10.1441

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