Article
Control of TCR V alpha-mediated positive repertoire selection and alloreactivity by differential J alpha usage and CDR3 alpha composition.
International immunology - 1 Oct 1997
Torres-Nagel N, Deutschländer A, Herrmann T, Arden B, Hünig T
Abstract excerpt
In rats expressing the f allele of the rat MHC (RT1f), CD8 T cells utilizing the V alpha 8.2 segment are 10-fold overselected during thymic development, resulting in V alpha 8.2 expression by 14% of mature CD8 T cells as compared to 1-2% in MHC congenic strains. In the alloreactive responses of C...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- CD8-Positive T-Lymphocytes
- DNA Primers
- DNA, Complementary
- Immunoglobulin Variable Region
- In Vitro Techniques
- Isoantigens
- Major Histocompatibility Complex
- Molecular Sequence Data
- Polymerase Chain Reaction
- Rats
- Rats, Inbred Lew
- Receptors, Antigen, T-Cell, alpha-beta