Article
The genetic basis of negative selection of Tcrb-V11+ T cells.
Immunogenetics - 1 Jan 1991
Tomonari K, Fairchild S
Abstract excerpt
Non-H-2 genes responsible for negative selection of Tcrb-V11+ T cells were examined using backcross mice of various strains with C58, which does not delete Tcrb-V11+ T cells. Two independently segregating genes were found: one leading to partial deletion was closely linked to Ly-2/Ly-3 on chromosome 6, and the second giving virtually complete deletion has not yet been mapped. The A strain had only the former,...
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