Ligand Binding Mechanism and Its Relationship with Conformational Changes in Adenine Riboswitch.

Abstract excerpt

Riboswitches are naturally occurring RNA aptamers that control the expression of essential bacterial genes by binding to specific small molecules. The binding with both high affinity and specificity induces conformational changes. Thus, riboswitches were proposed as a possible molecular target for developing antibiotics and chemical tools. The adenine riboswitch can bind not only to purine analogues but also to...

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• Ligands
• Guanine
• Adenine
• Molecular Dynamics Simulation
• Nucleic Acid Conformation