Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thermodynamic and kinetic characterization of ligand binding to the purine riboswitch aptamer domain.

Journal of molecular biology - 9 Jun 2006

Gilbert Sunny D, Stoddard Colby D, Wise Sarah J, Batey Robert T

Abstract excerpt

Riboswitches are cis-acting genetic regulatory elements found commonly in bacterial mRNAs that consist of a metabolite-responsive aptamer domain coupled to a regulatory switch. Purine riboswitches respond to intracellular concentrations of either adenine or guanine/hypoxanthine to control gene expression. The aptamer domain of the purine riboswitch contains a pyrimidine residue (Y74) that forms a Watson-Crick...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 2-Aminopurine
Share to 5' Untranslated Regions
Share to Adenine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aptamers, Nucleotide

Share to Guanine

Share to Purines

Share to Regulatory Sequences, Ribonucleic Acid

Share to RNA, Bacterial

Source

Identifiers

PMID: 16650860
DOI: 10.1016/j.jmb.2006.04.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thermodynamic and kinetic characterization of ligand binding to the purine riboswitch aptamer domain.PMID 16650860Read ↗

Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch.Semantic proximity Read ↗

Ligand Binding Mechanism and Its Relationship with Conformational Changes in Adenine Riboswitch.Semantic proximity Read ↗

Ligand Selectivity Mechanism and Conformational Changes in Guanine Riboswitch by Molecular Dynamics Simulations and Free Energy Calculations.Semantic proximity Read ↗

Mutational analysis of the purine riboswitch aptamer domain.Semantic proximity Read ↗

Structure-based principles underlying ligand recognition of xanthine-II riboswitch.Semantic proximity Read ↗

Insights into xanthine riboswitch structure and metal ion-mediated ligand recognition.Semantic proximity Read ↗

Ligand-mediated and tertiary interactions cooperatively stabilize the P1 region in the guanine-sensing riboswitch.Semantic proximity Read ↗

Dissecting the influence of Mg2+ on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domain.Semantic proximity Read ↗

Requirements for efficient ligand-gated co-transcriptional switching in designed variants of the B. subtilis pbuE adenine-responsive riboswitch in E. coli.Semantic proximity Read ↗

Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain.Semantic proximity Read ↗

A structural intermediate pre-organizes the add adenine riboswitch for ligand recognition.Semantic proximity Read ↗

Riboswitch structure: an internal residue mimicking the purine ligand.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.