Article
Influence of ground-state structure and Mg2+ binding on folding kinetics of the guanine-sensing riboswitch aptamer domain.
Nucleic acids research - 1 Dec 2011
Buck Janina, Wacker Anna, Warkentin Eberhart, Wöhnert Jens, Wirmer-Bartoschek Julia, Schwalbe Harald
Abstract excerpt
Riboswitch RNAs fold into complex tertiary structures upon binding to their cognate ligand. Ligand recognition is accomplished by key residues in the binding pocket. In addition, it often crucially depends on the stability of peripheral structural elements. The ligand-bound complex of the guanine-sensing riboswitch from Bacillus subtilis, for example, is stabilized by extensive interactions between apical loop...
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