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Article

Ligand-mediated and tertiary interactions cooperatively stabilize the P1 region in the guanine-sensing riboswitch.

PloS one - 1 Jan 2017

Hanke Christian A, Gohlke Holger

Abstract excerpt

Riboswitches are genetic regulatory elements that control gene expression depending on ligand binding. The guanine-sensing riboswitch (Gsw) binds ligands at a three-way junction formed by paired regions P1, P2, and P3. Loops L2 and L3 cap the P2 and P3 helices and form tertiary interactions. Part of P1 belongs to the switching sequence dictating the fate of the mRNA. Previous studies revealed an intricate...

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Identifiers

PMID: 28640851
DOI: 10.1371/journal.pone.0179271
PMCID: PMC5480868

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Source receipt: pubmed, retrieved 7 Sept 2026.

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