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Article

Riboswitch structure: an internal residue mimicking the purine ligand.

Nucleic acids research - 1 Apr 2010

Delfosse Vanessa, Bouchard Patricia, Bonneau Eric, Dagenais Pierre, Lemay Jean-François, Lafontaine Daniel A, Legault Pascale

Abstract excerpt

The adenine and guanine riboswitches regulate gene expression in response to their purine ligand. X-ray structures of the aptamer moiety of these riboswitches are characterized by a compact fold in which the ligand forms a Watson-Crick base pair with residue 65. Phylogenetic analyses revealed a strict restriction at position 39 of the aptamer that prevents the G39-C65 and A39-U65 combinations, and mutational...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adenine

Share to Aptamers, Nucleotide

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Share to Nuclear Magnetic Resonance, Biomolecular

Share to Regulatory Sequences, Ribonucleic Acid

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Source

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Identifiers

PMID: 20022916
DOI: 10.1093/nar/gkp1080
PMCID: PMC2847212

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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