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Article

Cytoplasmic PML function in TGF-beta signalling.

Nature - 9 Sept 2004

Lin Hui-Kuan, Bergmann Stephan, Pandolfi Pier Paolo

Abstract excerpt

Transforming growth factor beta (TGF-beta) is a pluripotent cytokine that controls key tumour suppressive functions, but cancer cells are often unresponsive to it. The promyelocytic leukaemia (PML) tumour suppressor of acute promyelocytic leukaemia (APL) accumulates in the PML nuclear body, but cytoplasmic PML isoforms of unknown function have also been described. Here we show that cytoplasmic Pml is an essential...

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Source

Identifiers

PMID: 15356634
DOI: 10.1038/nature02783

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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