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Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia

25 Nov 2003

Abstract excerpt

The promyelocytic leukemia (PML) tumor suppressor of acute promyelocytic leukemia (APL) is essential for a number of proapoptotic and growth-suppressive pathways as well as for the activity of differentiating agents such as retinoic acid (RA). In human APL, the dose of PML is reduced to heterozygosity given that one allele is involved in the chromosomal translocation while the status of the remaining PML allele...

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PMID: 14630830
DOI: 10.1182/blood-2003-07-2200

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