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Article

Role of Promyelocytic Leukemia (Pml) Protein in Tumor Suppression

19 Feb 2001

Abstract excerpt

The promyelocytic leukemia (PML) gene encodes a putative tumor suppressor gene involved in the control of apoptosis, which is fused to the retinoic acid receptor alpha (RARalpha) gene in the vast majority of acute promyelocytic leukemia (APL) patients as a consequence of chromosomal translocations. The PMLRARalpha oncoprotein is thought to antagonize the function of PML through its ability to heterodimerize with...

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PMID: 11181703
DOI: 10.1084/jem.193.4.521

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