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Article

Characterization of Endogenous Human Promyelocytic Leukemia Isoforms

15 Jun 2006

Abstract excerpt

Promyelocytic leukemia (PML) has been implicated in a variety of functions, including control of TP53 function and modulation of cellular senescence. Sumolated PML is the organizer of mature PML bodies, recruiting a variety of proteins onto these nuclear domains. The PML gene is predicted to encode a variety of protein isoforms. Overexpression of only one of them, PML-IV, promotes senescence in human diploid...

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PMID: 16778193
DOI: 10.1158/0008-5472.can-05-3792

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