Article
The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells.
Blood - 15 Apr 2007
Kishimoto Hiroyuki, Ohteki Toshiaki, Yajima Nobuyuki, Kawahara Koichi, Natsui Miyuki, Kawarasaki Satoru, Hamada Koichi, Horie Yasuo, Kubo Yoshiaki, Arase Seiji, Taniguchi Masaru, Vanhaesebroeck Bart, Mak Tak Wah, Nakano Toru, Koyasu Shigeo, Sasaki Takehiko, Suzuki Akira
Abstract excerpt
The tumor suppressor PTEN is mutated in many human cancers. We previously used the Cre-loxP system to generate mice (LckCrePten mice) with a Pten mutation in T-lineage cells. Here we describe the phenotype of Pten-deficient Valpha14iNKT cells. A failure in the development of Valpha14iNKT cells occurs in the LckCrePten thymus between stage 2 (CD44(high)NK1.1(-)) and stage 3 (CD44(high)NK1.1(+)), resulting in...
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