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Article

DOCK2 is required in T cell precursors for development of Valpha14 NK T cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2006

Kunisaki Yuya, Tanaka Yoshihiko, Sanui Terukazu, Inayoshi Ayumi, Noda Mayuko, Nakayama Toshinori, Harada Michishige, Taniguchi Masaru, Sasazuki Takehiko, Fukui Yoshinori

Abstract excerpt

Mouse CD1d-restricted Valpha14 NKT cells are a unique subset of lymphocytes, which play important roles in immune regulation, tumor surveillance and host defense against pathogens. DOCK2, a mammalian homolog of Caenorhabditis elegans CED-5 and Drosophila melanogaster myoblast city, is critical for lymphocyte migration and regulates T cell responsiveness through immunological synapse formation, yet its role in...

Topics

Animals
Antigen Presentation
Antigens, CD1
Antigens, CD1d
Female
GTPase-Activating Proteins
Galactosylceramides
Guanine Nucleotide Exchange Factors
Killer Cells, Natural
Liver

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Knockout

Phenotype

Receptors, Antigen, T-Cell, alpha-beta

Spleen

Stem Cells

T-Lymphocytes

Source

Identifiers

PMID: 16585555
DOI: 10.4049/jimmunol.176.8.4640

Genes

DOCK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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DOCK2 is required in T cell precursors for development of Valpha14 NK T cells.PMID 16585555Read ↗

Identification of CD4(-)CD8(-) double-negative natural killer T cell precursors in the thymus.Semantic proximity Read ↗

DOCK2 sets the threshold for entry into the virtual memory CD8 <sup>+</sup> T cell compartment by negatively regulating tonic TCR triggeringSemantic proximity Read ↗

Selective requirement for c-Myc at an early stage of V(alpha)14i NKT cell development.Semantic proximity Read ↗

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.Semantic proximity Read ↗

DOCK2-deficiency causes defects in anti-viral T cell responses and poor control of herpes simplex virus infectionSemantic proximity Read ↗

The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells.Semantic proximity Read ↗

The essential role of DOCK8 in humoral immunity.Semantic proximity Read ↗

Targeted Expression of Human CD1d in Transgenic Mice Reveals Independent Roles for Thymocytes and Thymic APCs in Positive and Negative Selection of Vα14i NKT CellsSemantic proximity Read ↗

Cytokine production and migration of in vitro-expanded NK1.1(-) invariant Valpha14 natural killer T (Valpha14i NKT) cells using alpha-galactosylceramide and IL-2.Semantic proximity Read ↗

Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity.Semantic proximity Read ↗

IL-21 Rescues the Defect of IL-10-Producing Regulatory B Cells and Improves Allergic Asthma in DOCK8 Deficient Mice.Semantic proximity Read ↗

Mouse CD1-specific NK1 T cells: development, specificity, and function.Semantic proximity Read ↗

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