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Article

Pik3ip1 Is a Negative Immune Regulator that Inhibits Antitumor T-Cell Immunity

26 Jul 2019

Abstract excerpt

Abstract Purpose: Multiple negative regulators restrict the ability of T cells to attack tumors. This work demonstrates the role of PI3K-interacting protein 1 (Pik3ip1) in restraining T-cell responses and antitumor immunity. Experimental Design: An anti-Pik3ip1 mAb was generated to identify the Pik3ip1 expression pattern of hematopoietic cells. Pik3ip1−/− mice and a Pik3ip1 fusion protein were generated to...

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PMID: 31350312
DOI: 10.1158/1078-0432.ccr-18-4134

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