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Article

PTEN regulates natural killer cell trafficking in vivo

2 Feb 2015

Abstract excerpt

Phosphatase and tensin homolog (PTEN) is a critical negative regulator of the phosphoinositide-3 kinase pathway, members of which play integral roles in natural killer (NK) cell development and function. However, the functions of PTEN in NK cell biology remain unknown. Here, we used an NK cell-specific PTEN-deletion mouse model to define the ramifications of intrinsic NK cell PTEN loss in vivo. In these mice,...

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Identifiers

PMID: 25646418
DOI: 10.1073/pnas.1413886112

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