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PIK3CA in <i> Kras <sup>G12D</sup> /Trp53 <sup>R172H</sup> </i> Tumor Cells Promotes Immune Evasion by Limiting Infiltration of T Cells in a Model of Pancreatic Cancer

2019-01-15

Abstract excerpt

<h4>ABSTRACT</h4> The presence of tumor-infiltrating T cells is associated with favorable patient outcomes, yet most pancreatic cancers are immunologically silent and resistant to currently available immunotherapies. Here we show using a syngeneic orthotopic implantation model of pancreatic cancer that Pik3ca regulates tumor immunogenicity. Genetic silencing of Pik3ca in Kras G12D /Trp53 R172H -driven pancre...

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Literature Corpus work
6b3b740e-7c0b-5e48-899f-196c89da40f2
DOI
10.1101/521831
Open publication

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