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Article

The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation.

The Journal of experimental medicine - 29 Sept 2008

Guo Hailong, Samarakoon Asanga, Vanhaesebroeck Bart, Malarkannan Subramaniam

Abstract excerpt

Phosphatidylinositol 3-kinases (PI3Ks) play a critical role in regulating B cell receptor- and T cell receptor-mediated signaling. However, their role in natural killer (NK) cell development and functions is not well understood. Using mice expressing p110 delta(D910A), a catalytically inactive p110 delta, we show that these mice had reduced NK cellularity, defective Ly49C and Ly49I NK subset maturation, and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18809712
DOI: 10.1084/jem.20072327
PMCID: PMC2556795

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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