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Article

Selective requirement for c-Myc at an early stage of V(alpha)14i NKT cell development.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2009

Mycko Marcin P, Ferrero Isabel, Wilson Anne, Jiang Wei, Bianchi Teresa, Trumpp Andreas, MacDonald H Robson

Abstract excerpt

Valpha14 invariant (Valpha14i) NKT cells are a subset of regulatory T cells that utilize a semi-invariant TCR to recognize glycolipids associated with monomorphic CD1d molecules. During development in the thymus, CD4(+)CD8(+) Valpha14i NKT precursors recognizing endogenous CD1d-associated glycolipids on other CD4(+)CD8(+) thymocytes are selected to undergo a maturation program involving sequential expression of...

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Share to CD8-Positive T-Lymphocytes
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Interleukin-4

Share to Natural Killer T-Cells

Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins c-myc

Share to Receptors, Antigen, T-Cell, alpha-beta

Source

Identifiers

PMID: 19342639
DOI: 10.4049/jimmunol.0803394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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