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Methylation Status of Imprinting Centers for <i>H19/IGF2</i> and <i>SNURF/SNRPN</i> in Primate Embryonic Stem Cells

14 Dec 2006

Abstract excerpt

Embryonic stem cells (ESCs) hold promise for cell and tissue replacement approaches to treating human diseases based on their capacity to differentiate into a wide variety of somatic cells and tissues. However, long-term in vitro culture and manipulations of ESCs may adversely affect their epigenetic integrity, including imprinting. We have recently reported aberrant biallelic expression of IGF2 and H19 in...

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PMID: 17170068
DOI: 10.1634/stemcells.2006-0120

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