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Article

Symmetric and asymmetric DNA methylation in the human IGF2-H19 imprinted region.

Genomics - 1 Mar 2000

Vu T H, Li T, Nguyen D, Nguyen B T, Yao X M, Hu J F, Hoffman A R

Abstract excerpt

The two contiguous IGF2 (human insulin-like growth factor II) and H19 genes are reciprocally imprinted in both human and mouse. In most tissues, IGF2 is transcribed only from the paternal chromosome while H19 is transcribed only from the maternal allele. The presence of a differential methylation region (DMR) on the two parental alleles at the 5' flanking region of H19 has been proposed to constitute the gametic...

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Source

Identifiers

PMID: 10729220
DOI: 10.1006/geno.1999.6094

Genes

IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Symmetric and asymmetric DNA methylation in the human IGF2-H19 imprinted region.PMID 10729220Read ↗

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Placenta-specific epimutation at H19-DMR among common pregnancy complications: its frequency and effect on the expression patterns of H19 and IGF2Semantic proximity Read ↗

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The human and mouse H19 imprinting control regions harbor an evolutionarily conserved silencer element that functions on transgenes in Drosophila.Semantic proximity Read ↗

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Mechanisms of Igf2/H19 Imprinting: DNA Methylation, Chromatin and Long-Distance Gene RegulationSemantic proximity Read ↗

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Quantitative allele-specific expression and DNA methylation analysis of H19, IGF2 and IGF2R in the human placenta across gestation reveals H19 imprinting plasticity.Semantic proximity Read ↗

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