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Article

Disruption of imprinting and aberrant embryo development in completely inbred embryonic stem cell-derived mice.

Development, growth & differentiation - 1 Sept 2007

Deng Tao, Kuang Ying, Zhang Dan, Wang Long, Sun Ruilin, Xu Guojiang, Wang Zhugang, Fei Jian

Abstract excerpt

The completely embryonic stem (ES) cell-derived mice (ES mice) produced by tetraploid embryo complementation provide us with a rapid and powerful approach for functional genome analysis. However, inbred ES cell lines often fail to generate ES mice. The genome of mouse ES cells is extremely unstable during in vitro culture and passage, and the expression of the imprinted genes is most likely to be affected....

Topics

Animals
Base Sequence
DNA Methylation
DNA Primers
Embryonic Development
Embryonic Stem Cells
Genomic Imprinting
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17635532
DOI: 10.1111/j.1440-169X.2007.00955.x

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