Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Culture-dependent decoupling of H19 allele-specific expression from H19/IGF2:IG-DMR methylation in experimental models.

Epigenetics - 1 Dec 2026

Selenou Céline, Brioude Frédéric, Sudre Laure, Pham Aurélie, Netchine Irène, Sobrier Marie-Laure, Giabicani Éloïse

Abstract excerpt

Genomic imprinting is an epigenetic mechanism leading to the monoallelic expression of a subset of genes, mainly regulated by DNA methylation at imprinting control regions (ICRs). Silver-Russell syndrome (SRS) is a paradigmatic imprinting disorder in which loss of methylation at the 11p15.5 H19/IGF2:IG-DMR is associated with downregulation of IGF2 and biallelic expression of H19. Currently, the allele-specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dental Pulp
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Genomic Imprinting

Share to Induced Pluripotent Stem Cells

Share to Insulin-Like Growth Factor II

Share to RNA, Long Noncoding

Share to Silver-Russell Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 42531143
DOI: 10.1080/15592294.2026.2690360
PMCID: PMC13432853

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Culture-dependent decoupling of H19 allele-specific expression from H19/IGF2:IG-DMR methylation in experimental models.PMID 42531143Read ↗

Dental pulp stem cells as a promising model to study imprinting diseasesSemantic proximity Read ↗

Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: association with aberrant phenotypes.Semantic proximity Read ↗

Monoallelic expression and methylation of imprinted genes in human and mouse embryonic germ cell lineages.Semantic proximity Read ↗

Methylation Status of Imprinting Centers for <i>H19/IGF2</i> and <i>SNURF/SNRPN</i> in Primate Embryonic Stem CellsSemantic proximity Read ↗

The transcriptional status but not the imprinting control region determines allele-specific histone modifications at the imprinted H19 locus.Semantic proximity Read ↗

Locus-Specific and Stable DNA Demethylation at the H19/IGF2 ICR1 by Epigenome Editing Using a dCas9-SunTag System and the Catalytic Domain of TET1.Semantic proximity Read ↗

Visualizing allele-specific expression in single cells reveals epigenetic mosaicism in an H19 loss-of-imprinting mutant.Semantic proximity Read ↗

Maternal imprinting at the H19–Igf2 locus maintains adult haematopoietic stem cell quiescenceSemantic proximity Read ↗

Allele-specific expression and total expression levels of imprinted genes during early mouse development: implications for imprinting mechanisms.Semantic proximity Read ↗

Igf2-H19, an imprinted tandem gene, is an important regulator of embryonic development, a guardian of proliferation of adult pluripotent stem cells, a regulator of longevity, and a ‘passkey’ to cancerogenesisSemantic proximity Read ↗

Epigenetic modulation of the IGF2/H19 imprinted domain in human embryonic and extra-embryonic compartments and its possible role in fetal growth restriction.Semantic proximity Read ↗

Dynamic readjustment of parental methylation patterns of the 5'-flank of the mouse H19 gene during in vitro organogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.