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Article

The human and mouse H19 imprinting control regions harbor an evolutionarily conserved silencer element that functions on transgenes in Drosophila.

Development genes and evolution - 1 Dec 2006

Arney Katharine L, Bae Esther, Olsen Cory, Drewell Robert A

Abstract excerpt

Differentially methylated regions have been characterized at a number of imprinted gene complexes with important roles in the regulation of monoallelic expression of one or more genes. The differentially methylated imprinting control region (ICR) located upstream of the murine H19 gene has been shown to control the imprinted expression of H19 and the coordinately regulated Igf2 gene by acting as a transcriptional...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17016732
DOI: 10.1007/s00427-006-0102-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The human and mouse H19 imprinting control regions harbor an evolutionarily conserved silencer element that functions on transgenes in Drosophila.PMID 17016732Read ↗

Regulatory mechanisms at the mouse Igf2/H19 locus.Semantic proximity Read ↗

Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region.Semantic proximity Read ↗

Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2.Semantic proximity Read ↗

Mechanisms of Igf2/H19 Imprinting: DNA Methylation, Chromatin and Long-Distance Gene RegulationSemantic proximity Read ↗

A complex duplication created by gene targeting at the imprinted H19 locus results in two classes of methylation and correlated Igf2 expression phenotypes.Semantic proximity Read ↗

Analysis of sequence upstream of the endogenous H19 gene reveals elements both essential and dispensable for imprinting.Semantic proximity Read ↗

Developmental profile of H19 differentially methylated domain (DMD) deletion alleles reveals multiple roles of the DMD in regulating allelic expression and DNA methylation at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

Role for DNA methylation in genomic imprinting.Semantic proximity Read ↗

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.Semantic proximity Read ↗

Humanized H19/Igf2 locus reveals diverged imprinting mechanism between mouse and human and reflects Silver-Russell syndrome phenotypes.Semantic proximity Read ↗

H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.Semantic proximity Read ↗

Symmetric and asymmetric DNA methylation in the human IGF2-H19 imprinted region.Semantic proximity Read ↗

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