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Article

Induced DNA demethylation can reshape chromatin topology at the IGF2-H19 locus

12 Apr 2013

Abstract excerpt

Choriocarcinomas are embryonal tumours with loss of imprinting and hypermethylation at the insulin-like growth factor 2 (IGF2)-H19 locus. The DNA methyltransferase inhibitor, 5-Aza-2'deoxycytidine (5-AzaCdR) is an approved epigenetic cancer therapy. However, it is not known to what extent 5-AzaCdR influences other epigenetic marks. In this study, we set out to determine whether 5-AzaCdR treatment can reprogram...

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PMID: 23585276
DOI: 10.1093/nar/gkt240

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Induced DNA demethylation can reshape chromatin topology at the IGF2-H19 locusPMID 23585276Read ↗

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