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Article

Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Sept 2004

Canals Josep M, Pineda José R, Torres-Peraza Jesús F, Bosch Miquel, Martín-Ibañez Raquel, Muñoz M Teresa, Mengod Guadalupe, Ernfors Patrik, Alberch Jordi

Abstract excerpt

The mechanism that controls the selective vulnerability of striatal neurons in Huntington's disease is unclear. Brain-derived neurotrophic factor (BDNF) protects striatal neurons and is regulated by Huntingtin through the interaction with the neuron-restrictive silencer factor. Here, we demonstrate that the downregulation of BDNF by mutant Huntingtin depends on the length and levels of expression of the CAG...

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Identifiers

PMID: 15342740
DOI: 10.1523/JNEUROSCI.1197-04.2004
PMCID: PMC6729627

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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