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Article

Huntington's disease.

Handbook of experimental pharmacology - 1 Jan 2014

Zuccato Chiara, Cattaneo Elena

Abstract excerpt

Changes in the level and activity of brain-derived neurotrophic factor (BDNF) have been described in a number of neurodegenerative disorders since early 1990s. However, only in Huntington disease (HD) gain- and loss-of-function experiments have mechanistically linked these abnormalities with the genetic defect.In this chapter we will describe how huntingtin protein, whose mutation causes HD, is involved in the...

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Source

Identifiers

PMID: 24668480
DOI: 10.1007/978-3-642-45106-5_14

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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