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Article

Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 Apr 2013

Liot Géraldine, Zala Diana, Pla Patrick, Mottet Guillaume, Piel Matthieu, Saudou Frédéric

Abstract excerpt

Huntingtin (HTT), the protein mutated in Huntington's disease (HD), controls transport of the neurotrophin, brain-derived neurotrophic factor (BDNF), within corticostriatal neurons. Transport and delivery of BDNF to the striatum are reduced in disease, which contributes to striatal neuron degeneration. BDNF released by cortical neurons activates TrkB receptors at striatal dendrites to promote striatum survival....

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Source

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Identifiers

PMID: 23575829
DOI: 10.1523/JNEUROSCI.2033-12.2013
PMCID: PMC6619069

Genes

BDNF
HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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