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Article

Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 24 Aug 2016

Hong Yan, Zhao Ting, Li Xiao-Jiang, Li Shihua

Abstract excerpt

UNLABELLED: Brain-derived neurotrophic factor (BDNF) is essential for neuronal differentiation and survival. We know that BDNF levels decline in the brains of patients with Huntington's disease (HD), a neurodegenerative disease caused by the expression of mutant huntingtin protein (mHtt), and furthermore that administration of BDNF in HD mice is protective against HD neuropathology. BDNF is produced in neurons,...

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Source

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Identifiers

PMID: 27559163
DOI: 10.1523/JNEUROSCI.0168-16.2016
PMCID: PMC4995297

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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