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Article

BDNF Binds Its Pro-Peptide with High Affinity and the Common Val66Met Polymorphism Attenuates the Interaction.

International journal of molecular sciences - 12 May 2017

Uegaki Koichi, Kumanogoh Haruko, Mizui Toshiyuki, Hirokawa Takatsugu, Ishikawa Yasuyuki, Kojima Masami

Abstract excerpt

Most growth factors are initially synthesized as precursors then cleaved into bioactive mature domains and pro-domains, but the biological roles of pro-domains are poorly understood. In the present study, we investigated the pro-domain (or pro-peptide) of brain-derived neurotrophic factor (BDNF), which promotes neuronal survival, differentiation and synaptic plasticity. The BDNF pro-peptide is a post-processing...

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Identifiers

PMID: 28498321
DOI: 10.3390/ijms18051042
PMCID: PMC5454954

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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