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Article

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases.

Nature reviews. Neuroscience - 1 Jun 2013

Lu Bai, Nagappan Guhan, Guan Xiaoming, Nathan Pradeep J, Wren Paul

Abstract excerpt

Increasing evidence suggests that synaptic dysfunction is a key pathophysiological hallmark in neurodegenerative disorders, including Alzheimer's disease. Understanding the role of brain-derived neurotrophic factor (BDNF) in synaptic plasticity and synaptogenesis, the impact of the BDNF Val66Met polymorphism in Alzheimer's disease-relevant endophenotypes - including episodic memory and hippocampal volume - and...

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Source

Identifiers

PMID: 23674053
DOI: 10.1038/nrn3505

Genes

BDNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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