Article
Action mechanism of human SMUG1 uracil-DNA glycosylase.
Nucleic acids symposium series (2004) - 1 Jan 2005
Matsubara Mayumi, Tanaka Tamon, Terato Hiroaki, Ide Hiroshi
Abstract excerpt
The DNA lesions resulting from deamination or oxidation of bases are generally repaired by the base excision repair pathway initiated by damage-specific DNA glycosylases. Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) present in vertebrates and insects excises not only uracil but also uracil derivatives bearing an oxidized group at ring-C5 from DNA, indicating roles in the repair of both...
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