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Article

SMUG2 DNA glycosylase from Pedobacter heparinus as a new subfamily of the UDG superfamily.

The Biochemical journal - 7 Mar 2017

Pang Panjiao, Yang Ye, Li Jing, Wang Zhong, Cao Weiguo, Xie Wei

Abstract excerpt

Base deamination is a common type of DNA damage that occurs in all organisms. DNA repair mechanisms are essential to maintain genome integrity, in which the base excision repair (BER) pathway plays a major role in the removal of base damage. In the BER pathway, the uracil DNA glycosylase superfamily is responsible for excising the deaminated bases from DNA and generates apurinic/apyrimidinic (AP) sites. Using...

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Identifiers

PMID: 28049757
DOI: 10.1042/BCJ20160934

Genes

SMUG1

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