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Inhibition of Uracil DNA Glycosylase Alters Frequency and Spectrum of Action-at-a-Distance Mutations Induced by 8-Oxo-7,8-dihydroguanine.

Biological & pharmaceutical bulletin - 1 Jan 2024

Suzuki Tetsuya, Yoshida Saho, Kamiya Hiroyuki

Abstract excerpt

The generation of DNA damage causes mutations and consequently cancer. Reactive oxygen species are important sources of DNA damage and some mutation signatures found in human cancers. 8-Oxo-7,8-dihydroguanine (GO, 8-hydroxyguanine) is one of the most abundant oxidized bases and induces a G→T transversion mutation at the modified site. The damaged G base also causes untargeted base substitution mutations at the G...

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PMID: 38987176
DOI: 10.1248/bpb.b24-00258

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