Article

UV-DDB as a General Sensor of DNA Damage in Chromatin: A Direct Role in Base Excision Repair

2023-05-31

Abstract excerpt

Base excision repair (BER) is a cellular process that removes damaged bases arising from exogenous and endogenous sources including reactive oxygen species, alkylation agents, and ionizing radiation. BER is mediated by the actions of multiple proteins that work in a highly concerted manner to resolve DNA damage efficiently to prevent toxic repair intermediates. During the initiation of BER, the damaged base is rem...

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Literature Corpus work: 36d38649-f2fa-5e52-bf44-1c1ea0682248
DOI: 10.20944/preprints202305.2170.v1

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