Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.

Scientific reports - 3 Aug 2017

Alsøe Lene, Sarno Antonio, Carracedo Sergio, Domanska Diana, Dingler Felix, Lirussi Lisa, SenGupta Tanima, Tekin Nuriye Basdag, Jobert Laure, Alexandrov Ludmil B, Galashevskaya Anastasia, Rada Cristina, Sandve Geir Kjetil, Rognes Torbjørn, Krokan Hans E, Nilsen Hilde

Abstract excerpt

Both a DNA lesion and an intermediate for antibody maturation, uracil is primarily processed by base excision repair (BER), either initiated by uracil-DNA glycosylase (UNG) or by single-strand selective monofunctional uracil DNA glycosylase (SMUG1). The relative in vivo contributions of each glycosylase remain elusive. To assess the impact of SMUG1 deficiency, we measured uracil and 5-hydroxymethyluracil, another...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CpG Islands
Share to Cytosine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deamination

Share to Dinucleoside Phosphates

Share to Genome

Share to Genomics

Share to Uracil

Share to Uracil-DNA Glycosidase

Source

Open in PubMed Open full text

Identifiers

PMID: 28775312
DOI: 10.1038/s41598-017-07314-5
PMCID: PMC5543110

Genes

SMUG1
UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.PMID 28775312Read ↗

Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.Semantic proximity Read ↗

Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1.Semantic proximity Read ↗

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair.Semantic proximity Read ↗

Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation.Semantic proximity Read ↗

Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.Semantic proximity Read ↗

Refining the Neuberger model: Uracil processing by activated B cells.Semantic proximity Read ↗

DNA Glycosylases Define the Outcome of Endogenous Base Modifications.Semantic proximity Read ↗

B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.Semantic proximity Read ↗

Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosineSemantic proximity Read ↗

Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosine.Semantic proximity Read ↗

Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy.Semantic proximity Read ↗

Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.