Rat 7,8-dihydro-8-oxoguanine DNA glycosylase: substrate specificity, kinetics and cleavagemechanism at an apurinic site.

doi:10.1093/nar/26.22.5199

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Article

Rat 7,8-dihydro-8-oxoguanine DNA glycosylase: substrate specificity, kinetics and cleavagemechanism at an apurinic site.

Nucleic acids research - 15 Nov 1998

Prieto Alamo M J, Jurado J, Francastel E, Laval F

Abstract excerpt

Reactive oxygen species produce different lesions in DNA. Among them, 7,8-dihydro-8-oxoguanine (8-oxoG) is one of the major oxidative products implicated in mutagenesis. This lesion is removed from damaged DNA by base excision repair, and genes coding for 8-oxoG-DNA glycosylases have been isolate...

Topics

Animals
Base Sequence
Catalytic Domain
Cloning, Molecular
DNA Glycosylases
DNA Primers
DNA, Complementary
DNA-Formamidopyrimidine Glycosylase
Escherichia coli
Escherichia coli Proteins
Humans
Kinetics
Mutation
N-Glycosyl Hydrolases
Oligodeoxyribonucleotides
Phenotype
Rats
Recombinant Proteins

Source

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Identifiers

PMID: 9801319
DOI: 10.1093/nar/26.22.5199
PMCID: PMC147981

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9801319-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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