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Article

Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1.

Molecular cell - 1 Jun 2003

Wibley Jane E A, Waters Timothy R, Haushalter Karl, Verdine Gregory L, Pearl Laurence H

Abstract excerpt

Cytosine deamination is a major promutagenic process, generating G:U mismatches that can cause transition mutations if not repaired. Uracil is also introduced into DNA via nonmutagenic incorporation of dUTP during replication. In bacteria, uracil is excised by uracil-DNA glycosylases (UDG) related to E. coli UNG, and UNG homologs are found in mammals and viruses. Ung knockout mice display no increase in mutation...

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Source

Identifiers

PMID: 12820976
DOI: 10.1016/s1097-2765(03)00235-1

Genes

SMUG1
UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1.PMID 12820976Read ↗

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