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Article

Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1.

International journal of radiation biology - 1 May 2009

Knaevelsrud Ingeborg, Slupphaug Geir, Leiros Ingar, Matsuda Akira, Ruoff Peter, Bjelland Svein

Abstract excerpt

PURPOSE: The aim of this study was to determine the excision efficiency of hSMUG1 (human single-strand-selective monofunctional uracil-DNA glycosylase) for 5-formyluracil (fU), a major thymine lesion formed by ionizing radiation, opposite all normal bases in DNA, to possibly explain mutation induction by fU in the DNA of mammalian cells. MATERIALS AND METHODS: An enzymatically [(32)P]labelled fU-containing 36...

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Source

Identifiers

PMID: 19365746
DOI: 10.1080/09553000902818915

Genes

SMUG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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